Strong is the voice of numerous animated creations, including main roles in Fillmore! as Ingrid Third; The Fairly OddParents as Timmy Turner and Poof; Rugrats and All Grown Up! as Dil Pickles; The Powerpuff Girls as Bubbles; Ben 10 as Ben Tennyson, Upgrade, Blitzwolfer, and Buzzshock; Teen Titans and the second version of this show called Teen Titans Go! as Raven; Foster's Home for Imaginary Friends as Terrence; the singing voice of Meg Griffin and additional voices on Family Guy; and My Little Pony: Friendship Is Magic as Twilight Sparkle.
In addition to film and television, Strong has also lent her voice to English-language localizations of Japanese anime such as Spirited Away and Princess Mononoke, as well as several video games, including her work as Elisa and Ursula in Metal Gear Solid: Portable Ops; Paz Ortega Andrade in Metal Gear Solid: Peace Walker; Rikku in Final Fantasy X, its sequel Final Fantasy X-2, and Kingdom Hearts II; Talwyn Apogee in Ratchet & Clank Future: Tools of Destruction and its sequel, Ratchet & Clank Future: Quest for Booty; Harley Quinn in Batman: Arkham City, replacing Arleen Sorkin from the franchise; and Juliet Starling, the main character of Lollipop Chainsaw. An avid user of social media, Strong won the Shorty Award for "Best #Actress" in 2013 thanks to a strong showing by her fans. The Behind the Voice Actors website selected her for a BTVA Voice Acting Award for Voice Actress of the Year for 2013, and nominated her for the 2011 and 2012 years.
Tara can be heard in in the films Animal Crackers, Injustice 2 as Harley Quinn, Charming, The My Little Pony Movie, reprising her role as Twilight Sparkle.