Kane is also a prominent video game voice actor, appearing in numerous titles - from bit parts, to major roles such as Gandalf, Professor X and lead characters in many Star Wars games like Star Wars: The Force Unleashed as Imperial Captain Ozzik Sturn, Lobot and Kento Marek (the father of Sam Witwer's Galen Marek) thanks to ILM's motion capture technology. In Call of Duty: World at War, Call of Duty: Black Ops, Call of Duty: Black Ops II and Call of Duty: Black Ops III, he provides the voice of Takeo Masaki, a Japanese WWII soldier in the Zombies game mode.
In the arena of non-animation voiceover work, Kane records commercials, film trailers and television promos. In addition, he has been the announcer for the AFI Life Achievement Award show twice, as well as the 78th, 80th, 83rd, and 84th Academy Awards. His most recent performance was as Odin (the father of Thor and Loki) in the video game adaption of Thor as well as the Disneyland attraction: Thor: Treasures of Asgard, taking over the role from Anthony Hopkins from the film.
On April 13, 2012, Kane took over for Joe Hursh as the voice of the Walt Disney World Monorail System. In 2013, he took over as the announcer of The Eric Andre Show, replacing Gary Anthony Williams.
Kane made his debut in the Star Wars film saga as the voice of Admiral Ackbar in 2017's Star Wars: The Last Jedi, taking over the role from the late Erik Bauersfeld. He had experience in voicing the character on several occasions for video games in the franchise prior to the film's release.